Serum IL-10 from systemic lupus erythematosus patients
suppresses the differentiation and function of monocyte-derived
dendritic cells
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Graphical Abstract
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Abstract
The role played by cytokines, other than interferon (IFN)-α, in the differentiation and function of dendritic cells
(DCs) in systemic lupus erythematosus (SLE), remains unclear. Serum interleukin-10 (IL-10) levels are generally
elevated in SLE patients, which might modulate the differentiation of DCs. In this study, DCs were induced from
monocytes either by transendothelial trafficking or by culture with granulocyte-macrophage colony-stimulating
factor (GM-CSF) + IL-4 + tumor necrosis factor (TNF)-α. Both systems were used to investigate the effects of
elevated serum IL-10 level on DC differentiation in SLE patients. The results showed that monocyte-derived DCs
induced by either SLE serum or exogenous IL-10 reduced the expression of human leukocyte antigen (HLA)-DR
and CD80, decreased IL-12p40 level, and increased IL-10 level, and exhibited an impaired capacity to stimulate
allogenic T-cell proliferation. These results indicate that serum IL-10 may be involved in the pathogenesis of SLE
by modulating the differentiation and function of DCs.
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