Morphological and molecular basis of ovarian serous carcinoma

Daniel G Rosen; Zhihong Zhang; Weiwei Shan; Jinsong Liu

doi:10.1016/S1674-8301(10)60036-X

PDF
Cite
Share

facebook

twitter

google

linkedin

Volume 24 Issue 4

Jun. 2010

Turn off MathJax

Article Contents

Abstract

The Journal of Biomedical Research > 2010 > 24(4): 257-263. > DOI: 10.1016/S1674-8301(10)60036-X

Daniel G Rosen, Zhihong Zhang, Weiwei Shan, Jinsong Liu. Morphological and molecular basis of ovarian serous carcinoma[J]. The Journal of Biomedical Research, 2010, 24(4): 257-263. DOI: 10.1016/S1674-8301(10)60036-X

Citation:

PDF (1516 KB)

Morphological and molecular basis of ovarian serous carcinoma

1.
Department of Pathology, the University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
2.
Department of Pathology, the University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA/Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China

More Information

Received Date: May 19, 2010

Graphical Abstract

Abstract

Abstract

Serous carcinoma is the most common type of epithelial ovarian cancer. In this review, we provide a com-prehensive picture of ovarian serous cancers from multiple aspects: the first part of this review summarizes the morphological, histological, and immunological signatures of ovarian serous carcinoma; subsequently, we review the history of the evolvement of different grading systems used in ovarian serous cancer; in the end, we focus on characterizing the genetics that underlie the 2-tiered pathways through which ovarian serous cancers are believed to arise: the low-grade and the high-grade pathways.
- ovarian carcinoma,
- grading,
- morphology,
- molecular genetics,
- tumorigenesis